Liquid Zeolites in high doses has been shrinking human and horse tumors. Almost 5'' across-3'' tall and 2'' in depth. In just 2 days it has shrunk by over 1'', picute on the right is at 2 weeks.

Insulin Resistance and Cushing’s syndrome in horses
Insulin Resistance and Cushing’s syndrome in horses
Adapted from a paper originally written in 2001, AHVMA conference.
Introduction
Cushing’s syndrome in horses is currently being frequently diagnosed. However, The symptoms seen in horses labeled with Cushing’s syndrome range from mild to severe and can begin as early as seven years of age. Horses in their late teens and over twenty years old can exhibit many of the “classic” signs of Cushing’s disease including hursutism, polyuria/polydypsia, muscle wasting and refractory laminitis (2, 3). However, many of the younger horses show poor or slow shedding, obesity with lumpy fat pads, poor immune systems, chronic infections and, in some cases, laminitis.
The potential reasons for the apparent increase in the insulin resistance and Insulin resistance-type condition in horses are not totally clear, however there are a number of risk factors that need to be examined. Some of these factors include stress, high sugar content feeds, overuse of drugs and vaccines, genetics, and potentially the feeding of soy products, the frequent use of pyrethroid-based fly sprays and possibly the feeding of large amounts of glucosamine.
Physiology and pathophysiology
Glucose metabolism
Glucose, being water soluble, needs help being transported across the lipid membrane of the cell. The primary way for glucose to be transported into muscle and adipose cells is facilitated diffusion using the transmembrane protein GLUT 4. GLUTs 1, 2, 3 and 5 are transmembrane proteins used in other aspects of glucose transport. GLUT 4 remains inside the cell until it is activated by a stimulus such as insulin, exercise or a compound such as vanadium, all of which move the GLUT 4 into the cell membrane to transport glucose (4). One of the main reasons for insulin resistance is defects in the intra-cellular action of GLUT 4 preventing a normal response to insulin.
Insulin resistance
Many “Cushing’s horses” have elevated insulin levels in their blood (5 Garcia) without concurrently raised or lowered glucose levels (6, 7, 8 Beech, Loeb, Reed). Insulin resistance is a group of symptoms related to hyperinsulinemia (1). The cells show an inability to transport glucose into them. Insulin resistance occurs in as much as 25% of the non-diabetic population (9). Cushing’s syndrome in horses has some of the same characteristics as Insulin resistance (5, 9) has in people. Some of the specific symptoms are obviously different, however, the general seriousness of the metabolic derangements are very similar, including glucose metabolism and circulatory problems.
People who are susceptible to insulin resistance are frequently from a genetic type considered “thrifty” or in horse terms, “easy keepers” (10, 11). In this type of individual, horse or human, the body is very efficient at storing fat for times of need, and in fact, if fed less, they often become more efficient at storing fat. In humans much of the fat stored from impaired glucose metabolism is distributed centrally, especially around the abdomen. Many horses store their fat in specific places; fat pads on their body, fat above the eyes and cresty necks. The fat on their body frequently becomes lumpy instead of smooth and often this is the first sign that the horse’s metabolism is changing. In fact, if this author sees a horse that has changed from smooth fat to lumpy fat, no matter what the age of the horse is, that horse will be a candidate for treatment as all conditions are easier to treat at the earliest sign of the disease.
The cardiac involvement that occurs in humans may not be directly related to the syndrome in horses, however, no research has been done in this area. Insulin affects the growth of smooth muscle cells in the arteries as well as lipogenesis in arterial vessels. Whether that has direct bearing on the laminitic horse remains to be seen. Dihydroepiandrosterone (DHEA) levels are not monitored in horses, however, in humans increases in insulin levels in some studies are shown to cause a decrease in DHEA. The decrease in DHEA is considered a cardiac disease risk factor.
In horses, it is not uncommon to see elevated insulin levels with normal blood glucose levels. In ambulatory equine practice, where it is often several hours or more until the blood samples are processed, it may also be necessary to collect a special glucose tube to get an accurate measure of blood glucose. The insulin is elevated because it is not able to get into the cells. Normally when a sugar or carbohydrate is eaten, the blood sugar levels increase, insulin is secreted by the pancreas, glucose is carried into the cells by the insulin and the blood sugar goes back to normal. In insulin resistance, the cell wall insulin receptors cannot transport glucose correctly (12, 13). About 25% of the hyperinsulinemic people become NIDDM, however, in horses, the actual occurrence of diabetes is quite low, indicating a difference in physiologic response between the two species.
Hyperinsulinemia may contribute to hypertension through altering sodium and potassium metabolism. Hypertension does not occur in the equine, though it is unknown whether some of the electrolyte imbalances occur and what effect this may have.
The treatment of people with Insulin resistance using natural medicine incorporates many of the ingredients used when successfully treating the “Cushing’s” horses. The permeability of the cell walls to insulin is enhanced and nutrients are provided to help insulin and glucose pathways function better. The details are discussed below in the treatment section.
Many dogs fit the clinical picture of insulin resistance and diabetes, however this author has not collected any data at this time. Many dogs are extremely resistant to losing weight, gain weight on air, yet are not truly hypothyroid. Dogs do have more true hypothyroid problems than horses do. The therapy for Insulin resistance may prove to be very helpful in treating the obese dogs as well.








